Bucolome in prevention of hyperbilirubinaemia in preterm infants.
نویسندگان
چکیده
Fifty preterm babies were randomly assigned to a group given oral bucolome (30 mg/kg per day for 5 days) and a control group. Serum bilirubin levels of the treated infants from day 4 onwards were consistently lower than those of the control infants. 3 of the 25 control infants (but none of the 25 treated infants) had bilirubin levels greater than 18 mg/100 ml (308 mumol/l) and required exchange transfusion. No sedation or drowsiness was observed in the infants given bucolome, and though the drug caused some vomiting, weight gains were unaffected.
منابع مشابه
Effect of bucolome in preterm infants.
Sir, Segni et al. (Archives, 1977, 52, 549) reported the prevention of hyperbilirubinaemia in premature infants by bucolome. The effect of bucolome on hyperbilirubinaemia in Gilbert's syndrome was well established by observation ofabout 30 cases ofthesyndrome(Yamamoto et al., 1974). However, as for the mechanism of the effect, we found that bucolome showed no induction of liver microsomal enzym...
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عنوان ژورنال:
- Archives of disease in childhood
دوره 52 7 شماره
صفحات -
تاریخ انتشار 1977